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Clear cell renal cell carcinoma (ccRCC) is an aggressive malignancy with limited treatment options and high rates of resistance to first-line kinase inhibitors. Current therapies largely target the tumor microenvironment, leaving intrinsic tumor vulnerabilities underexplored. Here, we ...
In advanced renal cell carcinoma, risk stratification identifies intermediate- and poor-risk patients who achieve superior overall survival with first-line IO/TKI combinations compared to monotherapy.
In a groundbreaking study published in the British Journal of Cancer, researchers have delved into the intricate exposure-response (E/R) relationship of two noteworthy immunotherapeutic agents,
In a groundbreaking study published in the Journal of Translational Medicine, researchers led by Peng et al. embarks on a profound exploration of the circular RNA known as CircCCDC66 and its integral
In a phase 1 trial testing healthy donor fecal microbial transplantation with immune checkpoint blockade in patients with previously untreated renal cell carcinoma, treatment was safe with an encouraging response signal and microbiome analyses, suggesting specific donor taxa associations with ...
In a double-blind, placebo-controlled phase 2 trial in patients with metastatic renal cell carcinoma treated with anti-PD-1 plus a VEGFR tyrosine kinase inhibitor, donor fecal microbial transplantation (FMT) from complete responders to immunotherapy did not significantly improve the primary ...
Fumarate hydratase-deficient renal cell carcinoma is a rare type of renal cell carcinoma often associated with hereditary leiomyomatosis and renal ...
Renal cell carcinoma (RCC) is an immunogenic tumor in which tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs) ...
Background Clear cell renal cell carcinoma (ccRCC) is a prevalent and aggressive form of kidney cancer with a poor prognosis. The tumor mutational burden (TMB) has been a subject of considerable interest in various cancer studies. However, the relationship between TMB and ccRCC has been ...
Smoking has been implicated as a potential factor influencing cancer progression and outcomes in various malignancies, including metastatic renal cell carcinoma (mRCC). This study aimed to evaluate the effect of smoking status on treatment outcomes in mRCC patients, with a focus on metastatic ...
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Articles from Kidney Cancer UK
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