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Tyrosine kinase inhibitors (TKIs) combined with immunotherapy have improved outcomes in advanced renal cell carcinoma (aRCC), yet resistance persists. This group presents single-cell transcriptomic profiling of aRCC patients treated with TKIs and immune checkpoint inhibitors, uncovering an ...
Although the use of tyrosine kinase inhibitors (TKIs), such as sunitinib, has led to impressive advancements in the treatment of clear cell renal cell carcinoma (ccRCC), primary or acquired resistance to sunitinib remains elusive. Here, we report that death receptor 5 (DR5) is upregulated in ...
A revolutionary non-surgical treatment developed at University Hospital Southampton is helping to transform care for kidney cancer.
Investigators sought to determine the effect of diabetes and metformin on renal cell carcinoma (RCC) outcomes.
Explore 10 ongoing clinical trials investigating immunotherapy strategies in renal cancer, including checkpoint inhibitors, HIF-2α inhibitors, microbiome-based therapies, and surgery-integrated approaches reshaping kidney cancer treatment.
PD-L1 May Predict Response to TKIs, VEGFs in Metastatic Clear Cell Renal Cell Carcinoma · Axitinib Shows Activity in Metastatic Renal Cell Carcinoma.
Brain metastases (BrM) in metastatic clear-cell renal cell carcinoma (m-ccRCC) are resistant to most systemic therapies, but respond better to cabozantinib. We documented intracranial response on common systemic therapies for m-ccRCC, described molecular mechanisms underlying efficacy or ...
ASCO GU 2026 Highlights: Belzutifan + Lenvatinib and Pembrolizumab in RCC – IUCS / ASCO, cancer, FASCO, Giuseppe Banna, GU26, immunotherapy, International
T1a RCC Death Risk Higher After Ablation vs Partial Nephrectomy · Assessing Recurrence Risk in Patients With Non-Clear Cell Renal Cell Carcinoma · SBRT ...
(HealthDay News) — For patients with stage T1a renal cell carcinoma (T1a RCC), ablation seems to be as effective as resection or nephrectomy, ...
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Articles from Kidney Cancer UK
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