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Treatment of early kidney cancer tumors with ablation therapy can be as effective as more invasive open surgery at stopping progression.
MSD has announced findings from the pivotal Phase III LITESPARK-022 trial, assessing the Keytruda-Welireg combination as adjuvant therapy for patients with clear cell RCC after nephrectomy.
... show that combinatorial therapies may provide new treatment options for patients with renal cell carcinoma or muscle-invasive bladder cancer.
Recent advances in cancer research have unveiled a promising new approach to predicting the metastatic potential of renal cell carcinoma (RCC) using 3D invasion properties of cell lines studied in
In a groundbreaking study published in Nature Communications, researchers have uncovered a crucial transcriptional regulatory loop involving Hypoxia-Inducible Factors (HIFs) that sustain the
The mechanisms of increased EPAS1 transcription in clear cell renal cell carcinoma remain to be explored. Here, the authors propose a regulatory circuitry of EPAS1 expression which is dependent on HIF and lineage-specific transcription factors.
The advent of anti-PD-L1 antibodies has revolutionized the landscape of cancer therapy, particularly reshaping treatment paradigms for patients diagnosed with early-stage malignancies. Historically,
In a groundbreaking study poised to transform our understanding of renal carcinogenesis, researchers have unveiled a novel molecular mechanism by which CDK13 orchestrates the progression of clear cell
Clear-cell renal cell carcinoma (ccRCC) is often described as a “metabolic disease”, a malignancy that gets its name and biological identity from ...
Most guidelines still treat indeterminate (Rx) surgical margins after nephrectomy for renal cell carcinoma (RCC) as equivalent to negative (R0) ...
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Articles from Kidney Cancer UK
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