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Identification and validation of a ferroptosis-related signature for prediction of the prognosis and tumor microenvironment in patients with chromophobe renal cell carcinoma

Identification and validation of a ferroptosis-related signature for prediction of the prognosis and tumor microenvironment in patients with chromophobe renal cell carcinoma

Background Clear cell renal cell carcinoma (ccRCC), a common type of renal cortical tumor, is the most prevalent subtype of renal malignancies within the urinary system and is associated with a low survival rate. Ferroptosis plays a crucial role in the process of renal carcinogenesis and holds ...
EGR2-mediated regulation of m6A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization

EGR2-mediated regulation of m6A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization

Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cell carcinoma, and the tumour growth and metastasis of ccRCC are related to prognosis. N4-acetylcytidine (ac4C) is one of the major modifications of RNA and is known to be mediated by N-acetyltransferase ...
Frontiers | Extensive genotype-phenotype heterogeneity in renal cell carcinoma – a proof-of-concept study

Frontiers | Extensive genotype-phenotype heterogeneity in renal cell carcinoma – a proof-of-concept study

Background: Renal cell carcinoma (RCC) is characterized by a high degree of genomic but also functional intratumoral heterogeneity (ITH). Mutations in VHL, c...
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Articles from Kidney Cancer UK

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