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Background: Ferroptosis-related genes are essential in cancer development.However, the specific roles of ferroptosis-related genes in clear cell renal cell c...
Clear cell renal cell carcinoma (ccRCC) poses significant clinical challenges due to its high metastatic rate at diagnosis and resistance to conventional therapies. The magnesium transporter NIPAL4, involved in lipid metabolism and magnesium ion homeostasis, has recently been implicated in ...
In renal cell carcinoma (RCC), tissue inhibitor of metalloproteinase (TIMP) 3 expression is lost, suggesting that the TIMP3 gene may function as a tumor suppressor gene. Cadmium (Cd) and arsenic (As) exposure may affect the expression of TIMP3. Here we investigate the association of clear cell ...
Researchers linked higher weighted years with overweight/obesity to increased risk for overall, aggressive, fatal, and clear-cell renal cell carcinoma ...
Early data suggest use of the biomarker test may significantly reduce the need for surveillance imaging.
A new analysis calls into question the use of imaging alone to determine the efficacy of ablative radiation therapy.
Deletion of upstream tumor suppressors of the Hippo/YAP pathway is frequent in papillary renal cell carcinoma (pRCC). Here, the authors employ a transgenic mouse model, single-cell transcriptomics and public genomic datasets to show that targeting hyperactivated YAP1 prevents neoplastic renal ...
The AUR87A study found that urine collected biomarkers could accurately predict recurrence of kidney cancer in post-surgery patients.
The phase 2 STARLITE 2 trial is assessing 177Lu-girentuximab plus nivolumab in advanced clear cell renal cell carcinoma.
Tyrosine kinase inhibitor (TKI) and immune checkpoint inhibitor (ICI) combination therapy is emerging as a major therapeutic strategy for advanced clear cell renal cell carcinoma (ccRCC). To define the druggable targets for improvement of TKI and ICI combination therapy in ccRCC, we analyzed a ...
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Articles from Kidney Cancer UK
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