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Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation

Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation

By Lv, Xiangmin, Liu, Jiyuan, Islam, Kazi, Ruan, Jinpeng, He, Chunbo, Chen, Peichao, Huang, Cong, Wang, Hongbo, Dhar, Anjali, Moness, Madelyn, Shi, Davie, Murphy, Savannah, Zhao, Xingeng, Yang, Siyi, Montoute, Isabelle, Polakkattil, Aneeta, Chung, Andie, Ruiz, Emily, Carbajal, Brianna, Padavala, Alekhya, Chen, Li, Hua, Guohua, Chen, Xingcheng, Davis, John S. & Wang, Cheng | 10 April 2025 | Articles, Around the Web
The most notable progress in renal clear cell carcinoma (ccRCC) in the past decades is the introduction of drugs targeting the VHL-HIF signaling pathway-associated angiogenesis. However, mechanisms underlying the development of VHL mutation-independent ccRCC are unclear. Here we provide ...
Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation

Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation

By Lv, Xiangmin, Liu, Jiyuan, Islam, Kazi, Ruan, Jinpeng, He, Chunbo, Chen, Peichao, Huang, Cong, Wang, Hongbo, Dhar, Anjali, Moness, Madelyn, Shi, Davie, Murphy, Savannah, Zhao, Xingeng, Yang, Siyi, Montoute, Isabelle, Polakkattil, Aneeta, Chung, Andie, Ruiz, Emily, Carbajal, Brianna, Padavala, Alekhya, Chen, Li, Hua, Guohua, Chen, Xingcheng, Davis, John S. & Wang, Cheng | 10 April 2025 | Articles, Around the Web
The most notable progress in renal clear cell carcinoma (ccRCC) in the past decades is the introduction of drugs targeting the VHL-HIF signaling pathway-associated angiogenesis. However, mechanisms underlying the development of VHL mutation-independent ccRCC are unclear. Here we provide ...
Associations of dietary patterns with kidney cancer risk, kidney cancer-specific mortality and all-cause mortality among postmenopausal women

Associations of dietary patterns with kidney cancer risk, kidney cancer-specific mortality and all-cause mortality among postmenopausal women

By Taj, Tahir, Sundqvist, Pernilla, Wolk, Alicja, Fall, Katja & Ugge, Henrik | 5 April 2025 | Articles, Around the Web
A diet rich in fruits, vegetables, coffee, and tea, limited red meat, and moderate alcohol intake may reduce the risk of renal cell carcinoma (RCC). The anti-inflammatory potential of diet has been proposed as a mechanism influencing cancer risk. This study assessed the association between an ...
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