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New mouse models for exploring renal tumor extension into the inferior vena cava

New mouse models for exploring renal tumor extension into the inferior vena cava

By Wray, Rebecca, Paverd, Hania, Machado, Ines, Barbieri, Johanna, Easita, Farhana, Edwards, Abigail R., Gallagher, Ferdia A., Mendichovszky, Iosif A., Mitchell, Thomas J., de la Roche, Maike, Shields, Jacqueline D., Ursprung, Stephan, Wallis, Lauren, Warren, Anne Y., Welsh, Sarah J., Crispin-Ortuzar, Mireia, Stewart, Grant D. & Jones, James O. | 28 April 2025 | Articles, Around the Web
Venous tumour thrombus can occur within renal cell carcinoma, and can require complex additional surgery and treatment. Here, the authors analyse multiparametric data from patients treated with axitinib and develop a machine learning model to predict neoadjuvant treatment response.
Angiogenic and immune predictors of neoadjuvant axitinib response in renal cell carcinoma with venous tumour thrombus – Nature Communications

Angiogenic and immune predictors of neoadjuvant axitinib response in renal cell carcinoma with venous tumour thrombus – Nature Communications

By Wray, Rebecca, Paverd, Hania, Machado, Ines, Barbieri, Johanna, Easita, Farhana, Edwards, Abigail R., Gallagher, Ferdia A., Mendichovszky, Iosif A., Mitchell, Thomas J., de la Roche, Maike, Shields, Jacqueline D., Ursprung, Stephan, Wallis, Lauren, Warren, Anne Y., Welsh, Sarah J., Crispin-Ortuzar, Mireia, Stewart, Grant D. & Jones, James O. | 28 April 2025 | Articles, Around the Web
Venous tumour thrombus can occur within renal cell carcinoma, and can require complex additional surgery and treatment. Here, the authors analyse multiparametric data from patients treated with axitinib and develop a machine learning model to predict neoadjuvant treatment response.
Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p

Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p

By Yang, Yang, Qiang, Cheng, Jie, Zhu, Ce, Han, Yan, Huang, Xiu-bin, Li, Wen-mei, Fan, Xu, Zhang & Yu, Gao | 25 April 2025 | Articles, Around the Web
The interaction between tumor-derived exosomes and stroma plays a crucial role in tumor progression. However, the mechanisms through which tumor cells influence stromal changes are not yet fully understood. In our study, through single-cell sequencing analysis of clear cell renal cell ...
Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study

By Xu, Chenglong, Wei, Haotian, Wang, Yue, Ma, Xiaocheng, Li, Qi, Bi, Yingjie, Li, Zifei, Li, Zhaochen, Zhu, Shimiao, Tian, Jing, Quan, Changyi & Qi, Shiyong | 19 April 2025 | Articles, Around the Web
Recent studies have identified a biological process called adherent-to-suspension transition (AST) as a key factor in promoting metastasis. The involvement of AST in the progression of clear cell renal cell carcinoma (ccRCC) remains largely unexplored. We comprehensively investigated the ...
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