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Kidney Cancer News elsewhere on the Web

Integrating machine learning and multi-omics analysis to unveil key programmed cell death patterns and immunotherapy targets in kidney renal clear cell carcinoma – Scientific Reports

Integrating machine learning and multi-omics analysis to unveil key programmed cell death patterns and immunotherapy targets in kidney renal clear cell carcinoma – Scientific Reports

Kidney renal clear cell carcinoma (KIRC), a cancer characterized by substantial immune infiltration, exhibits limited sensitivity to conventional radiochemotherapy. Although immunotherapy has shown efficacy in some patients, its applicability is not universally effective. Studies have ...
MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1 – Cell Death Discovery

MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1 – Cell Death Discovery

Fructose-1, 6-bisphosphatase (FBP1) is a tumor suppressor and frequently deficient in various cancers, including clear cell renal cell carcinoma (ccRCC). VHL inactivation mutations are usually observed in ccRCC, which can lead to abnormal activation of the HIF signaling pathway. FBP1 could ...
Differentiation of low and high grade renal cell carcinoma on routine MRI with an externally validated automatic machine learning algorithm

Differentiation of low and high grade renal cell carcinoma on routine MRI with an externally validated automatic machine learning algorithm

Preoperative detection of pT3a invasion in non-metastatic renal cell carcinoma (RCC) remains challenging with CT. This study developed and validated radiomic models using preoperative CT to identify pT3a invasions. Six models were trained and internally validated via nested cross-validation on ...
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Articles from Kidney Cancer UK

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